Genomics translational activities
Project Members - Macquarie University
Hossai Gul - Research Assistant firstname.lastname@example.org
Project Main Description
Our health system is increasingly complex; constantly changing and adapting. Finding ways to understand that complexity in a holistic manner (avoiding the reductionist temptation to study single processes in isolation) is imperative if we are to understand how things work and how they can work better.
This project will increase our ability to understand complexity and network capacities by studying the Australian Genomics Health Alliance (AGHA) as an example of a complex adaptive system. The AGHA was funded to oversee and facilitate the introduction of genomic medicine into Australian health settings. This nationwide alliance of clinicians, scientists, researchers, and consumers across varied sites, conditions and contexts is sufficiently complex, yet bounded enough, to permit a holistic and dynamic exploration with the aim of documenting interactions, productivity, and ways to enhance systems performance. We will examine the AGHA for the key defining features of a complex adaptive system: semi-autonomous agents, dynamic, non-linear interactions, emergent behaviours and self-organisation. We will use a mixed method, longitudinal design to construct our picture of the AGHA.
The AGHA is bringing together a wide range of partner organisations to lead the integration of genomic medicine into healthcare across Australia. Genomic sequencing is an extremely complex process to introduce into already complex clinical settings and health delivery systems that are already under substantial pressure. Challenges include: structural (e.g. changed laboratory set ups, changed membership and process of multidisciplinary teams), financial (e.g. costs of the sequencing, workforce development issues), cognitive (e.g. understanding the complexity of curation and limitations of genomic testing), and cultural (e.g. medical paradigms and ways of working compared to genetic counselling).
The overarching aim of this two-year project is to describe the AGHA as a complex adaptive system using Rich Pictures, dynamic modelling and social network analyses to show organisations, individual agents, relationships, emergent features and behaviours, components (e.g., technology), key drivers, and contextual influences and how they inter-relate.
CHRIS Working paper #102
Leveraging features of complexity to drive implementation: a critical review of studies from clinical genomics
Janet C Long, Kate Churruca, Louise A Ellis, Hossai Gul, Elise McPherson, Stephanie Best, Aleksandra Olekahns, Jeffrey Braithwaite
- Long JC, Pomare C, Best S, Boughtwood T, North Kathryn, Ellis LA, Churruca K, Braithwaite J Building a learning community of Australian clinical genomics: a social network study of the Australian Genomic Health Alliance. BMC Medicine 2019; Feb 22
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Australian Genomics Health Alliance
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Content owner: Australian Institute of Health Innovation Last updated: 21 Nov 2019 5:03pm