Publications

Publications

You can also view our latest publications in the Macquarie University Research Portal.

Please email Andrew Piggott if you would like a copy of any of these articles.

  1. Li, H., Gilchrist, C.L.M., Lacey, H.J., Crombie, A., Vuong, D., Pitt, J.I., Lacey, E., Chooi, Y.H. and Piggott, A.M. "Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii", Org. Lett., 2019, 21, 1287-1291.
  2. Plisson, F. and Piggott, A.M. "Predicting Blood–Brain Barrier Permeability of Marine-Derived Kinase Inhibitors Using Ensemble Classifiers Reveals Potential Hits for Neurodegenerative Disorders", Mar. Drugs, 2019, 17, 81.
  3. Hu, J., Sarrami, F., Li, H., Zhang, G., Stubbs, K.A., Lacey, E., Stewart, S.G., Karton, A., Piggott, A.M. and Chooi, Y.H. "Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system", Chem. Sci., 2019, 10, 1457-1465.
  4. Li, H., Hu, J., Wei, H., Solomon, P.S., Vuong, D., Lacey, E., Stubbs, K.A., Piggott, A.M. and Chooi, Y.H. "Chemical Ecogenomics-guided Discovery of Phytotoxic α-Pyrones from the Fungal Wheat Pathogen Parastagonospora nodorum", Org. Lett., 2018, 20, 6148-6152.
  5. Chaudhary, N.K., Pitt, J.I., Lacey, E., Crombie, A., Vuong, D., Piggott, A.M. and Karuso, P. "Banksialactones and banksiamarins: isochromanones and isocoumarins from an Australian fungus, Aspergillus banksianus", J. Nat. Prod., 2018, 81, 1517-1526.
  6. Morshed, M.T., Vuong, D., Crombie, A., Lacey, A.E., Karuso, P. Lacey, E. and Piggott, A.M. "Expanding antibiotic chemical space around the nidulin pharmacophore", Org. Biomol. Chem., 2018, 16, 3038-3051.
  7. Vuong, D., Kaplan, M., Lacey, H.J., Crombie, A., Lacey, E. and Piggott, A.M. "A study of the chemical diversity of macroalgae from South Eastern Australia", Fitoterapia, 2018, 126, 53-64.
  8. Ragini, K., Piggott, A.M. and Karuso, P. "Crellasterones A and B: A-norsterol derivatives from the New Caledonian sponge Crella incrustans", Marine Drugs, 2017, 15, 177.
  9. Pitt, J.I., Lange, L., Lacey, A.E., Vuong, D., Midgley, D.J., Lacey, H.J., Greenfield, P., Bradbury, M.I., Lacey, E., Busk, P.K., Pilgaard, B., Chooi, Y.H. and Piggott, A.M. "Aspergillus hancockii sp. nov., a biosynthetically talented fungus endemic to southeastern Australian soils", PLoS One, 2017, 12, e0170254.
  10. Ragini, K., Fromont, J., Piggott, A.M., and Karuso, P. "Enantiodivergence in the biosynthesis of bromotyrosine alkaloids from sponges?", J. Nat. Prod., 2017, 80, 215-219.
  11. Zhang, S., De Leon Rodriguez, L.M., Lacey, E., Piggott, A.M., Leung, I.K.H. and Brimble, M.A. "Cyclisation of linear tetrapeptides containing N-methylated amino acids using 1-propanephosphonic acid anhydride", Eur. J. Org. Chem., 2017, 2017(1), 149-158.
  12. Moore, A.F., Lacey, H.J., Crombie, C., Lacey, E. and Piggott, A.M. "Primary pH degradation products of doramectin", Tetrahedron Lett., 2016, 57, 4224-4227.
  13. Piggott, A.M. and Karuso, P. "Identifying the cellular targets of natural products using T7 phage display", Nat. Prod. Rep., 2016, 33, 626-636.
  14. Hayashi, A., Crombie, A., Lacey, E., Richardson, A.J., Vuong, D., Piggott, A.M. and Hallegraeff, G. "Aspergillus sydowii marine fungal bloom in Australian coastal waters, its metabolites and potential impact on Symbiodinium dinoflagellates", Marine Drugs, 2016, 14, 59.
  15. Lacey, H.J., Vuong, D., Pitt, J.I., Lacey, E. and Piggott, A.M. "Kumbicins A–D: bis-indolyl benzenoids and benzoquinones from an Australian soil fungus, Aspergillus kumbius", Aust. J. Chem., 2016, 69, 152-160.
  16. Piggott, A.M., Salim, A.A. and Capon, R.J. "Chapter 12: Nuclear Magnetic Resonance Case Studies in Microbial Natural Products" in Applications of modern NMR approaches to the structure elucidation of natural products: Volume 2. Data Acquisition and Applications to Compound Classes. Williams, A. and Martin, G.E. eds., 2016 , pp. 440-485. RSC Publishing: UK.
  17. Salim, A.A., Piggott, A.M. and Capon, R.J. "Chapter 11: Nuclear Magnetic Resonance Case Studies in Marine Natural Products" in Applications of modern NMR approaches to the structure elucidation of natural products: Volume 2. Data Acquisition and Applications to Compound Classes. Williams, A. and Martin, G.E. eds., 2016 , pp. 403-439. RSC Publishing: UK.
  18. Khalil, Z., Raju, R., Piggott, A.M., Salim, A.A., Blumenthal, A. and Capon, R.J. "Aranciamycins I and J: Antimycobacterial anthracyclines from an Australian marine-derived Streptomyces sp.", J. Nat. Prod., 2015, 78, 949-952.
  19. Khalil, Z., Huang, X.C., Raju, R., Piggott, A.M. and Capon, R.J. "Shornephine A: Structure, chemical stability and P-glycoprotein inhibitory properties of a rare diketomorpholine from an Australian marine-derived Aspergillus sp.", J. Org. Chem., 2014, 79, 8700-8705.
  20. Salim, A.A., Xiao, X., Cho, K.-J., Piggott, A.M., Lacey, E., Hancock, J.F. and Capon, R.J. "Rare Streptomyces sp. polyketides as modulators of K-ras localisation", Org. Biomol. Chem., 2014, 12, 4872-4878.
  21. Hayes, R.A., Piggott, A.M., Smith, T.E. and Nahrung, H.F. "Corymbia phloem phenolics, tannins and terpenoids: interactions with a cerambycid borer", Chemoecology, 2014, 24, 95-103.
  22. Raju, R., Khalil, Z., Piggott, A.M., Blumenthal, A., Gardiner, D.L., Skinner-Adams, T.S., Capon, R.J. "Mollemycin A: An Antimalarial and Antibacterial Glyco-hexadepsipeptide-polyketide from an Australian Marine-Derived Streptomyces sp. (CMB-M0244)", Org. Lett., 2014, 16, 1716-1719.
  23. Plisson, F., Prasad, P., Xiao, X., Piggott, A.M., Huang, X.C., Khalil, Z. and Capon, R.J. "Callyspongisines A-D: bromopyrrole alkaloids from an Australian marine sponge, Callyspongia sp.", Org. Biomol. Chem., 2014, 12, 1579-1584.
  24. Liu, X., Song, F., Ma, L., Chen, C., Xiao, X., Ren, B., Liu, X., Dai, H., Piggott, A.M., Av-Gay, Y., Zhang, L. and Capon, R.J. "Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii", Tetrahedron Lett., 2013, 54, 6081-6083.
  25. Balansa, W., Islam, R., Fontaine, F., Piggott, A.M., Zhang, H., Xiao, X., Webb, T.I., Gilbert, D.F., Lynch, J.W., Capon, R.J. "Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia", Org. Biomol. Chem., 2013, 11, 4695-4701.
  26. Balansa, W., Islam, R., Gilbert, D.F., Fontaine, F., Xiao, X., Zhang, H., Piggott, A.M., Lynch, J.W., Capon, R.J. "Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator", Bioorg. Med. Chem., 2013, 21, 4420-4425.
  27. Wang, Q., Song, F., Xiao, X., Huang, P., Li, L., Monte, A., Abdel-Mageed, W.M., Wang, J., Guo, H., He, W., Xie, F., Dai, H., Liu, M., Chen, C., Xu, H., Liu, M., Piggott, A.M., Liu, X., Capon, R.J. and Zhang, L. "Abyssomicins from the South China Sea Deep-Sea Sediment Verrucosispora sp.: Natural Thioether Michael Addition Adducts as Antitubercular Prodrugs", Angew. Chem. Int. Ed., 2013, 52, 1231-1234.
  28. Cho, K.-J., Park, J.-H., Piggott, A.M., Salim, A.A., Gorfe, A., Capon, R.J., Lacey, E. and Hancock, J.F. "Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins", J. Biol. Chem., 2012, 287, 43573-43584.
  29. Raju, R., Piggott, A.M., Quezada, M. and Capon, R.J. "Nocardiopsins C and D and nocardiopyrone A: new polyketides from an  Australian marine-derived Nocardiopsis sp.", Tetrahedron, 2012, 69, 692-698.
  30. Song, F., Liu, X., Guo, H., Ren, B., Chen, C., Piggott, A.M., Yu, K., Gao, H., Wang, Q., Liu, M., Liu, X., Dai, H., Zhang, L. and Capon, R.J. "Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor", Org. Lett., 2012, 14, 4770-4773.
  31. Köhnke, M., Schmitt, S., Ariotti, N., Piggott, A.M., Parton, R.G., Lacey, E., Capon, R.J., Alexandrov, K. and Abankwa, D. "Design and Application of in vivo FRET Biosensors to Identify Protein Prenylation and Nanoclustering Inhibitors", Chem. Biol., 2012, 19, 866-874.
  32. Plisson, F., Conte, M., Khalil, Z., Huang, X.C., Piggott, A.M. and Capon, R.J. "Kinase inhibitor scaffolds against neurodegenerative diseases from a Southern Australian ascidian, Didemnum sp.", ChemMedChem, 2012, 7, 983-990.
  33. Xu, X.L., Piggott, A.M., Yin, L.Y., Capon, R.J. and Song, F.H. "Symphyocladins A-G: bromophenol adducts from a Chinese marine red alga, Symphyocladia latiuscula", Tetrahedron Lett., 2012, 53, 2103-2106.
  34. Raju, R., Piggott, A.M., Zhalil, Z., Bernhardt, P.V. and Capon, R.J. "Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.", Tetrahedron Lett., 2012, 53, 1063-1065.
  35. Ajala, O.S., Piggott, A.M., Plisson, F., Khalil, Z., Huang, X.C., Adesegun, S.A., Coker, H.A.B. and Capon, R.J." Ikirydinium A: a new indole alkaloid from the seeds of Huntaria umbellata (K. Schum)", Tetrahedron Lett., 2011, 52, 7125-7127.
  36. Raju, R., Piggott, A.M., Huang, X.C. and Capon, R.J. "Nocardioazines: A novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits P-glycoprotein", Org. Lett., 2011, 13, 2770-2773.
  37. Fremlin, L., Farrugia, M., Piggott, A.M., Khalil, Z., Lacey, E. and Capon, R.J. "Reveromycins Revealed: New polyketide spiroketals from Australian marine-derived and terrestrial Streptomyces spp. A case of natural products vs. artifacts", Org. Biomol. Chem., 2011, 9, 1201-1211.
  38. Cooper, M.A. and Piggott, A.M. "Back to the future: breathing new life into old antibiotics to fight superbugs", The Conversation, 2011, 30 May.
  39. Raju, R., Piggott, A.M., Barrientos Diaz, L.X., Khalil, Z.G. and Capon, R.J. "Heronapyrroles A-C: Farnesylated 2-Nitropyrroles from an Australian Marine-Derived Streptomyces sp.", Org. Lett., 2010, 12, 5158-5161.
  40. Raju, R., Piggott, A.M., Conte, M.M. and Capon, R.J. "Heronamides A-C, new polyketide macrolactams from an Australian marine-derived Streptomyces sp. A biosynthetic case for synchronized tandem electro-cyclization", Org. Biomol. Chem., 2010, 8, 4682-4689.
  41. Balansa, W., Islam, R., Fontaine, F., Piggott, A.M., Zhang, H., Webb, T.I., Gilbert, D., Lynch, J.W. and Capon, R.J. "Ircinialactams: Subunit-Selective Glycine Receptor Modulators from Australian Sponges of the Family Irciniidae", Bioorg. Med. Chem., 2010, 18, 2912-2919.
  42. Peng, C., Gunaherath, G.M.K.B., Piggott, A.M., Khalil, Z., Conte, M. and Capon, R.J. "9-(5'-deoxy-5'-thio-β-D-xylofuranosyl)adenine disulfide from the southern Australian marine sponge Trachycladus laevispirulifer: the first natural occurrence of a nucleoside disulfide", Aust. J. Chem., 2010, 63, 873-876.
  43. Raju, R., Piggott, A.M., Conte, M., Tnimov, Z., Alexandrov, K. and Capon, R.J. "Nocardiopsins: New FKBP12 Binding Macrolide Polyketides from an Australian Marine-Derived Actinomycete, Nocardiopsis sp.", Chem. Eur. J., 2010, 16, 3194-3200.
  44. Piggott, A.M., Kriegel, A.M., Willows, R.D. and Karuso, P. "Rapid isolation of novel FK506 binding proteins from multiple organisms using T7 phage display", Bioorg. Med. Chem., 2009, 17, 6841-6850.
  45. Raju, R., Piggott, A.M., Conte, M., Aalbersberg, W.G.L., Feussner, K. and Capon, R.J. "Naseseazines A and B: A New Dimeric Diketopiperazine Framework from a Marine-Derived Actinomycete, Streptomyces sp.", Org. Lett., 2009, 11, 3862-3865.
  46. Fremlin, L.J., Piggott, A.M., Lacey, E. and Capon, R.J. "Cottoquinazoline A and Cotteslosins A-B: Metabolites from an Australian Marine-Derived Strain of Aspergillus versicolor", J. Nat. Prod., 2009, 72, 666-670.
  47. Hayes, R.A., Piggott, A.M., Dalle, K. and Capon, R.J. "Microbial biotransformation as a source of chemical diversity in cane toad steroid toxins", Bioorg. Med. Chem. Lett., 2009, 19, 1790-1792.
  48. Capon, R.J., Hayes, R.A. and Piggott, A.M. “Chemists vs Cane Toads”, Engineering World, 2009 , August-September.
  49. Capon, R.J., Hayes, R.A. and Piggott, A.M. “Mythbusting - Cane Toads in Australia”, Chemistry in Australia, 2009 , 76, 3-6. (Magazine Cover)
  50. El-Naggar, M., Piggott, A.M. and Capon, R.J. "Bistellettazines A-C and Bistellettazole A: New Terpenyl-Pyrrolizidine and Terpenyl-Imidazole Alkaloids from a Southern Australian Marine Sponge, Stelletta sp.", Org. Lett., 2008, 10, 4247-4250.
  51. Piggott, A.M. and Karuso, P. "Rapid Identification of a Protein Binding Partner for the Marine Natural Product Kahalalide F using Reverse Chemical Proteomics", ChemBioChem, 2008, 9, 524-530.
  52. Piggott, A.M. and Karuso, P. "Fluorometric assay for the determination of glutathione reductase activity", Anal. Chem., 2007, 79, 8769-8773.
  53. Piggott, A.M. and Karuso, P. "Hydrolysis rates of alkyl and aryl sulfinamides: Evidence of general acid catalysis", Tetrahedron Lett., 2007, 48, 7452-7455.
  54. Van Es, T., Staskun, B. and Piggott, A.M. "The synthesis of 4-ethyl-2-propyl-3-substituted-pyrrolo[3,4-b]quinoline-1,9-dione derivatives from 3,3-dichloro-4-ethyl-thieno[3,4-b]quinoline-1,9-dione and propylamine", S. Afr. J. Chem., 2006, 59, 101-108.
  55. Piggott, A.M. and Karuso, P. "Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics", Tetrahedron Lett., 2005, 46, 8241-8244.
  56. Piggott, A.M. and Karuso, P. "9-hydroxyfurodysinin-O-ethyl lactone: A new sesquiterpene isolated from the tropical marine sponge Dysidea arenaria", Molecules, 2005, 10, 1292-1297.
  57. Piggott, A.M. and Karuso, P. "Quality, not Quantity: The Role of Natural Products in Drug Discovery and Reverse Chemical Proteomics", Marine Drugs, 2005, 3, 36-63.
  58. Piggott, A.M. and Karuso, P. "Quality, not Quantity: The Role of Natural Products and Chemical Proteomics in Modern Drug Discovery". Comb. Chem. High Throughput Screen., 2004, 7, 607-630.
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