Clinical trials

Clinical trials

Would you like to volunteer for a clinical trial?

If you would you like to be involved in research on Alzheimer’s disease, check out the information on our current clinical trials below.

Please also feel free to contact us if you are not eligible for any of the studies below, or if you have any suggestions or questions.  We will keep you in mind for our next study or put you in contact with other researchers who may be able to help you.

If you are not able to participate in any clinical trials but would still like to support our team and Alzheimer’s disease research, please consider a donation.

If you would like to collaborate with us, please don’t hesitate to get in contact.

Coconut oil in Alzheimer's Disease prevention – pilot study (COAD-P001)

If you are 50 to 80 years old and generally healthy, you can contribute for a study involving the investigation of coconut oil in the prevention of Alzheimer's disease in healthy adults and memory complainers.

It is hoped that the findings might idicate an alternative therapeutic avenue for Alzheimer's disease.

What will you be asked to do?

  • Complete some brief questionaires and memory tests and donate a fasting blood sample.
  • Consumption of coconut oil for 8 weeks.

If you are interested in assisting us with this study, please contact:

Your help will be greatly appreciated. Thank you.

ToTAL study (Testosterone-Omega Three (DHA) – Amyloid Lowering)

AARF logo

Volunteers needed!

Background

In 2018, the Australian Alzheimer’s Research Foundation together with researchers from Edith Cowan University (Perth, WA) and Macquarie University (Sydney, NSW) commenced the largest clinical trial to date to investigate the influence of testosterone on key markers of Alzheimer’s disease including amyloid beta, a protein mainly accumulating in the brains of individuals with the disease. There is currently no cure for Alzheimer’s disease.

Age-related decrease in testosterone levels in men has been linked to an increased risk of Alzheimer’s disease. Previous work by Professor Ralph Martins and his team has found that the effects of testosterone therapy may extend to both the accumulation and clearance of amyloid beta from the brain and may potentially prevent the disease.

The project will also study the effects of omega-3 fatty acids found in fish oil called DHA (Docosahexaenoic Acid). DHA is thought to protect brain cells from the damage caused by the accumulation of amyloid beta. It is hoped that combining fish oil with testosterone will have a stronger preventative effect.

Who can take part?

Man concerned about their memory, aged 60 to 80, free from any major or unstable medical conditions, who have a testosterone level on the low side of normal, and are not currently taking testosterone treatment. Other criteria will follow assessments at our NSW or WA sites.

You would like volunteer and do not know your testosterone level; we would still love to hear from you. We will collect a blood sample and test it for you.

What is required?

Participation requires initial screening to identify volunteers who are safe and suitable to take part. This is first done by a phone questionnaire, followed by two clinic visits to discuss the trial and your medical history with a study doctor, blood tests, and memory assessments. If eligible, you will be asked to undergo more memory testing, brain scans, and other assessments before and after being treated with testosterone and fish oil (or a placebo version of one or both) for a 56-week period. Participation is expected to last approximately 18 months.

Contact Details

If you would like to take part or would like further information, please contact:

Coconut oil in Alzheimer’s Disease prevention – long-term clinical intervention (COAD-P002)

Coming soon.

If you are 50 to 80 years old and generally healthy, you can contribute for a study involving the investigation of coconut oil in the prevention of Alzheimer's disease in healthy adults and memory complainers.

It is hoped that the findings might idicate an alternative therapeutic avenue for Alzheimer's disease.

What will you be asked to do?

  • Complete some brief questionaires and memory tests and donate a fasting blood sample.
  • Consumption of coconut oil or a placebo for 26 weeks.

If you are interested in assisting us with this study, please contact:

Your help will be greatly appreciated. Thank you.

The Australian Dementia Network (ADNet): Bringing together Australia’s dementia stakeholders

ADN logo

Coming soon.

In this study we aim to organise a national registry of people interested in participating in studies to understand Alzheimer’s disease and to prevent the prevent it.

You will do some memory tests, donate a blood sample, have some body measurements taken and have brain imagine done (to investigate Amyloid beta and Tau protein). After that you will receive information on studies you are eligible for and you can decide if you would like to participate.

If you would like to volunteer, please contact:

The Australian-multidomain Approach to Reduce dementia Risk by protecting brain health with lifestyle intervention (AU-ARROW)

Coming soon.

In this study, we aim to determine if it is possible to prevent Alzheimer’s disease using lifestyle changes.

You will be asked to:

  • donate some blood samples
  • do some memory testing
  • have your body measurements taken
  • consume a healthy diet, do physical activity and do brain training activities for 24 months. These activities may be coached or not depending on the study group you are allocated to
  • some people will also have their brain imaged. This is optional.

If you would like to volunteer, please contact:

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