Decoding glycoprotein functions in human disease
We conduct fundamental biomedical-focused research exploring the importance of sugary-proteins (glycoproteins) in human health and disease.
With a strong focus on unpicking the glycobiology of the innate immune system, particularly neutrophils and macrophages, we aim to advance our molecular and cellular understanding of the role of glycoproteins in immune-related disorders. This includes their involvement in cancer, inflammation and pathogen infection (eg sepsis, tuberculosis, cystic fibrosis).
Our approach
We develop and apply advanced mass spectrometry-based methods in glycomics and glycoproteomics, drawing on approaches from:
- immunology
- molecular biology
- protein and carbohydrate chemistry
- structural biology
- other ‘omics' disciplines.
Our aim is to unravel the basic glycobiology of the innate immune system and to identify defects in the complex ‘glycoproteome’. Through this work, we decode the aberrations in the underpinning glycosylation machinery that are associated with human immune diseases.
Join or collaborate with us
We are a highly collaborative team. Please contact our group leader Professor Morten Andersen if you are interested in more details regarding:
- our research
- student research projects
- fellowship opportunities
- potential research collaborations.