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Itsu Sen (Yi Qian)

Professor, Biomechanics

Biomedical Sciences

Contact Details

Tel: 02 9812 3551


2 Technology Place, Macquarie University NSW 2109, Australia

Prof. Sen (Qian) has 30 years continuous experience in computational fluid dynamics (CFD) research and application in bioengineering. He has worked in the field of circulatory assist and was instrumental in the development of the artificial heart program in Japan and in Australia. (Left Ventricular Assist Device, LVAD). He primarily developed the CFD technique which was employed for blood pump design. He used computational haemodynamic techniques to improve the problems related to haemolysis of the VentrAssit artificial heart which has been implanted in over 450 patients around world. He also has developed novel methodologies based on the CFD techniques for improvement cardiovascular and cerebrovascular surgical method, and estimation the risk of cerebral aneurysms. The system has been applied for over 300 patients, and validated by the results from in-vitro and in-vivo. He has more than 10 years work experience in global industry and has worked for eight universities in three different countries.

He has published and presented his research in Stroke, American Association of Neurological Surgeons (AANS), and American Society of Neuroradiology (ASNR). He has set up global collaborative links with biomedical engineers, neurosurgeons, cardiovascular surgeons and neuroradiologists in Australia, USA, Japan and China. Prof. Qian published over 50 peer reviewed articles and is a referee for many international journals including; Stroke, AJNR, ASME, and International Journal of Artificial Organs etc.


BS ME PhD (Tokyo)

Research Interests

  • Computational Fluid Dynamics (CFD)
  • Cerebral vascular and cardiovascular haemodynamics research.
  • Engineering-based surgical training
  • Medical imaging and molecular imaging.
  • Heart assistant device (Artificial heart) and endovascular treatment devices R&D
  • Intracranial aneurysm molecular features and biomarkers

Select Publications

  1. CJ Lee, Y Zhang, H Takao, Y Murayama, Y Qian, A fluid-structure interaction study using patient-specific ruptured and unruptured aneurysm: The effect of aneurysm morphology, hypertension and elasticity, Journal of Biomechanics, 46 (2013) 2402-2410.
  2. S F Sia, Y Qian, Y Zhang, M K Morgan, Mean Arterial Pressure Required for Intracranial Bypass Grafts: An Investigation with Computational Hemodynamic Models, Neurosurgery, 2012 Oct;71(4):826-31.
  3. H Takao, Y Murayama, S Otsuka, Y Qian, et al, Hemodynamic differences between unruptured and ruptured intracranial aneurysms during observation, Stroke, 43: 1436-9, 2012.
  4. Y Qian, H. Takao, M. Umezu and Y. Murayama, Risk Analysis of Unruptured Aneurysms Using Computed Fluid Dynamics Technology: Preliminary Results, AJNR Am J Neuroradiol. Nov-Dec; 32(10):1948-55, 2011.
  5. Y Qian, J L Liu, K Itatani, K Miyaji and M Umezu, Computational Hemodynamic Analysis in Congenital Heart Disease: Simulation of the Norwood Procedure, Annals of Biomedical Engineering Vol 38, No 7, 2302-2313, 2010.

Recent Grants

  • 2011-2013, ARC Discovery, Mechanisms of initiation and remodeling of intracranial aneurysms: a synthesis of haemodynamics and molecular biomarkers.
  • 2010-2013, ARC Linkage, Computational haemodynamics system for prediction of risk of rupture of cerebral aneurysms.
  • 2010-2013, Japan Society for the Promotion of Science (JSPS), Development of an aneurysm rupture estimation system associated with an accurate vessel thickness measurement technology.
  • 2011-2013,JSPS, The criteria for adulthood Tetralogy of Fallot (TF) surgical treatment based on Ultrasound MRI and hemodynamic simulation technology.
  • 2011-2013, JSPS, Using a physiologic blood simulation system to optimize pediatric complex cardiac anomaly surgery.
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