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Edwin (Chai) Lim

Senior Research Fellow

Biomedical Sciences, Faculty of Medicine and Health Sciences

Contact Details

Tel: 02 9850 2737


Level 1, 75 Talavera Road, Macquarie University

Dr Lim is a biochemist with a profound interest in tryptophan metabolomics of human pathology. This metabolic pathway is interesting because changes to this pathway in response to environmental stimuli such as pathogens or toxins can affect five important biological functions: sleep, mood/behavioural, protein synthesis, immune response and brain activity. His research combines functional metabolomics using mass spectrometry with molecular cell biology to understand how changes in the tryptophan metabolism may affect the outlined five important functions in our body during disease condition. Dr Lim’s work is highly translational with implication for biomarker discovery and biomarker-based precision medicine.


BSc (Hon I), PhD

Research Interests

  • Targeted tryptophan metabolomics as prognostic biomarker and precision medicine in human pathology
  • Role of hormones on tryptophan metabolism during inflammation
  • Screening of Chinese Medicines for novel modulators of the tryptophan metabolism

Select Publications

  1. Lim CK, Fernandez-Gomez FJ, Braidy N, Estrada C, Costa C, Costa S, Bessede A, Fernandez-Villalba E, Herrero MT, Guillemin GJ. (2016) Involvement of the kynurenine pathway in the pathogenesis of Parkinson’s disease. Progress in Neurobiology.  (In press)
  2. Lim CK, Essa MM, de Paula Martins R, Lovejoy DB, Waly MI, Al-Farsi YM, Al-Sharbati M, Al-Shaffae MA, Guillemin GJ. (2015) Altered kynurenine pathway metabolism in autism: implication for enhanced glutamatergic activity through immune activation. Autism Research. (Epub ahead of print)
  3. Sundaram G, Brew BJ, Jones SP, Lim CK*, Guillemin GJ*. (2014) Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies. J. Neuroinflammation. 11(1):204 *Shared senior authorship
  4. Erhardt S, Lim CK, Linderholm KR, Janelidze S, Lindqvist D, Samuelsson M, Lundberg K, Postolache TT, Träskman-Bendz L, Guillemin GJ, Brundin L. (2013) Connecting inflammation with glutamate agonism in suicidality. Neuropsychopharmacology. 38:743-752.

Recent Grants

2016 Society of Mental Health Research Early Career Researcher Award - $100,000

2016 Multiple Sclerosis Research Australia incubator grant (CIB) -$22,000

2016 Motor Neuron Disease Research Institute of Australia (CIE) - $249,710

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