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Nicholas Cole

Research Group Leader

Neurodegenerative Diseases Research Centre, Faculty of Medicine and Health Sciences

Contact Details

Tel: (02) 9850 2740

Email: nicholas.cole@mq.edu.au

2 Technology Place, Macquarie University

B.Sc. University of Liverpool. PhD. St Andrews University, UK. First post-doctorate, Dundee University. Second post-doctorate, The Victor Chang Cardiac Research Institute, Sydney. Lectureship, The University of Sydney. Senior Lectureship, Macquarie University, Sydney.

Qualification:

B.Sc. Hons. PhD

Research Interest

  • Motor Neurone Disease (MND)/Amyotrophic Lateral Sclerosis (ALS)
  • Frontotemporal dementia (FTD)
  • Neurodegenerative Disease
  • Development
  • Zebrafish

Select Publications

  1. Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype.
    Hogan AL, et al, Cole NJ. PMID: 28444311 Human Molecular Genetics (2017)
  2. The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger.
    Keightley MC, et al, Cole NJ, Traver D, Nutt SL, McCoey J, Buckle AM, Heath JK, Lieschke GJ. PMID: 28382966 Nature Communications (2017)
  3. Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy.
    Zhang Y, Nguyen DT, Olzomer EM, Poon GP, Cole NJ, Puvanendran A, Phillips BR, Hesselson D.PMID: 28366621 Cell Chemical Biology (2017).
  4. Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment-Controlled Multistage Drug-Release in Neurons.
    S
    hi B, et al, Cole N, Chung R. Small (2017)
  5. Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy.
    Morsch M, Radford RA, Don EK, Lee A, Hortle E, Cole NJ, Chung RS. PMID: 28190072
    Journal of Visualised Experiments (2017)
  6. A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease.
    Don EK, et al, Cole NJ. PMID: 27631880 Zebrafish (2017).
  7. A somitic contribution to the apical ectodermal ridge is essential for fin formation.
    Masselink W, Cole NJ, et al, Currie PD. PMID: 27437584 Nature. (2016)
  8. CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.
    Williams KL, et al, Cole NJ, Yerbury JJ, Atkin JD, Shaw CE, Nicholson GA, Blair IP.
    PMID: 27080313 Nature Communications (2016).
  9. Genetic basis of hindlimb loss in a naturally occurring vertebrate model.
    Don EK, et al, Cole NJ. PMID: 26892237 Biology Open (2016).
  10. In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord.
    Morsch M, et al, Cole NJ, Chung R. PMID: 26379496 Frontiers Cellular Neuroscience (2015).
  11. The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia.
    Radford RA, Morsch M, Rayner SL, Cole NJ, Pountney DL, Chung RS. PMID: 26578880 Frontiers Cellular Neuroscience. (2015).
  12. Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1.
    Nguyen PD, et al, Cole NJ, Alaei S, Ramialison M, Sutherland RL, Polo JM, Lieschke GJ, Currie PD. PMID: 25119043 Nature (2014)
  13. Mutant human FUS Is ubiquitously mislocalized and generates persistent stress granules in primary cultured transgenic zebrafish cells.
    Acosta JR, et al, Cole NJ. PMID: 24912067 PLoS One (2014).
    Accepted manuscripts in press

    Maria-Cristina Keightley et al,  The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger.Nature Communications(accepted Jan 2017)

    Shi. BY, Chen J, Morsch M, Lee A, Cole NJ et al, Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment Controlled Multistage Drug Release in Neurons. Small(accepted Feb 2017)

    Zhang Y, Nguyen DT, Olzomer EM, Poon GP, Cole NJ et al, Rescue of Pink1 deficiency by stress-dependent activation of autophagy.Cell Chemical Biology(accepted Feb 2017)

Grant Success

  • Cure for MND Foundation Research Grant . Elucidating the Pathogenesis of Sporadic Motor Neurone Disease Using Zebrafish Models Motor Neurone Disease Research Institute of Australia,2015
  • Peter Stearne Grant for Familial MND Research. Modelling the ALS-linked C9ORF72 Hexanucleotide Repeat Expansion in Zebrafish. Motorneurone Disease Research Institute of Australia, 2014
  • Dementia research Teams Grant (NHMRC), 2015-2020 $6,377,279. Developing insight into the molecular origins of familial and sporadic frontotemporal dementia. APP1095215.
  • Project Grant NHMRC 2015-2018 $676,000. Disruption to intracellular trafficking as a central pathogenic mechanism in amyotrophic lateral sclerosis (ALS). APP1086887
  • ARC Project Grant. 2014-2017 $383,000 Visualising neuron-glia interactions in the injured central nervous system. DP140103233
  • Project Grant NHMRC 2012-2015, $435,000 Investigating the pathogenesis of Motor Neurone Disease using zebrafish models. APP1034816
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