Motor Neuron Disease Research Centre
Level 1, 75 Talavera Road, Macquarie University
World-class proteomics and multiomics capabilities
The National NeuroProteomics Facility (NNPF) is dedicated to advancing research in motor neuron disease (MND) and neurodegeneration.
The NNPF is a specialised neurodegeneration research node of the Australian Proteome Analysis Facility (APAF), supported by Bioplatforms Australia (BPA).
Founded in 2025, the NNPF is funded by FightMND and brings together Australia’s leading expertise in:
- neurodegeneration
- proteomics
- systems biology.
Embedded within the Macquarie University Motor Neuron Disease (MND) Research Centre, the NNPF provides cutting-edge proteomics infrastructure, expertise and collaborative services for Australian researchers studying MND and other neurodegenerative diseases. The NNPF integrates with APAF to deliver end-to-end proteomics capabilities.
Our mission
Our mission is to empower researchers with advanced proteomic and multiomic technologies to decode the molecular basis of neurodegeneration and accelerate therapeutic discovery.
MND is a disease of proteinopathy – meaning its roots lie in the misfolding, aggregation and dysfunction of proteins. Our vision is to understand how these molecular processes can be accelerated using high-throughput proteomics approaches.
The NNPF was established to make these powerful analytical approaches accessible to all researchers, enabling:
- identification of clinical biomarkers and therapeutic targets
- identification of protein-protein and protein-RNA interactions in MND
- integration of proteomics with genomics and transcriptomics
- mechanistic studies of cellular pathways and protein aggregates
- translation of molecular insights into disease-modifying therapies.
Instrumentation available
- Ultimate 3000 nanoLC coupled to Thermo Q-Exactive Plus
- Vanquish Neo UHPLC coupled to Thermo Exploris 480
Collaborate with us
The NNPF operates as an open-access national facility. Researchers from academia, industry and clinical settings are encouraged to engage with us to design, execute and interpret proteomics studies tailored to their research questions.
We provide:
- bioinformatic data processing and interpretation
- collaborative publication support
- sample preparation and quality control
- study design and statistical guidance
- mass spectrometry analysis (DDA, DIA, targeted).
- Associate Professor Albert Lee – Academic Director
- Professor Roger Chung – Co-Director
- Dr Erin Sykes – Technical Proteomics Facility Manager
About FightMND
Founded in 2014 by Neale Daniher AO, Pat Cunningham and the late Dr Ian Davis OAM, FightMND is a not-for-profit organisation with a vision of a world free from motor neurone disease (MND). They work towards their vision by raising awareness and funding vital research to improve the quality of life and find treatments and, one day, a cure for those living with MND.