Adipose-derived cells in osteoarthritis
Chief investigators: Herbert, Packer, Vesey
Grant details
Provided by: Australian Research Council
Body fluids: sweet protection against infection?
Chief investigators: Packer, Nevalainen, Wilcox, Paulsen
Summary
We propose that the human innate immune system actually uses the infection mechanism of pathogens to its own advantage. The first step of bacterial and fungal infection is adhesion of the microorganism to the mucosal surface of the host epithelia.
We will show that secreted fluids that bathe these surfaces use these same protein-sugar interactions to bind the pathogens, which can then be expelled physically from the body. Tears and saliva will be used to determine whether their glycoproteins protect the eye and oral cavity respectively from infection by the main pathogens to which they are exposed. This knowledge will provide opportunities for the development of new and natural antimicrobial agents.
Grant details
Provided by: Australian Research Council Discovery Projects
Cortical link between cardiovascular health and mental illness
Chief investigators: Cornish, Haynes, Goodchild
Summary
We are using a novel integration of behavioural, cardiovascular and molecular techniques to discover the neurotransmitter and cellular basis of prefrontal cortex function. This will form part of a larger investigation to investigate in detail the neurotransmitters of the prefrontal cortex that regulate cardiovascular function and how changes to brain function (induced by methamphetamine exposure or environmental enrichment) alter the role of the prefrontal cortex and related circuits.
Grant details
Provided by: Macquarie University research and development grant
Developing new treatments for brain arteriovenous malformations: Identification of endothelial protein targets
Chief investigators: Stoodley, Molloy, Tu, Morgan, Smee
Grant details
Provided by: National Health and Medical Research Council
Inflammatory determinants for colorectal cancer treatment
Chief investigators: Charles, Molloy, Clarke
Grant details
Provided by: National Health and Medical Research Council
Mother’s sweet milk: boosting the baby’s protection against infection
Chief Investigators: Packer, Nevalainen, Paulsen, Power
Grant details
Provided by: Macquarie University internal research grant
Multiplexed quantitation of phosphoproteins in tumours as prognostic markers
Chief investigator: Molloy
Grant details
Provided by: Cancer Institute NSW (Innovation grant)
Plasma biomarkers for clinical outcome of colorectal cancer
Chief investigator: Molloy
Grant details
Provided by: Macquarie University safety net grant
Protein biomarkers of colorectal cancer
Chief investigator: Molloy
Grant details
Provided by: National Health and Medical Research Council (Careers Development Award)
The role of the interaction between sugars and proteins in the protection against pathogenic infection
Chief Investigator: Packer
Grant details
Provided by: Macquarie University Internal Research Grant