Owen Tan has background in molecular biology, health and commerce. His specific research interests include the economic impact of new technology in healthcare. His recent research focuses on developing microsimulation model to analyse the economic cost of implementing next-generation sequencing in patient care.
Schofield D J, Zeppel M J B, Tan O, Lymer S, Cunich M M & Shrestha R N (2018). A Brief, Global History of Microsimulation Models in Health: Past Applications, Lessons Learned and Future Directions. International Journal of Microsimulation, 11(1): 97-142
Tan O, Shrestha R, Cunich M and Schofield D J (2018) Application of Next-Generation Sequencing to Improve Cancer Management: A Review of the Clinical Effectiveness and Cost-Effectiveness. Clin Genet, 93(3), 533-44
Owen Tan, Rupendra Shrestha, Michelle Cunich, Deborah J Schofield (2018) Application of next generation sequencing to improve cancer management: A review of the clinical effectiveness and cost effectiveness Clinical Genetics 93:533-544 DOI: 101111/cge13199
Bingul M, Tan O, Gardner C R, Sutton S K, Arndt G M, Marshall G M, Cheung BB, Kumar N and Black, DS (2016) Synthesis, Characterization and Anti-Cancer Activity of Hydrazide Derivatives Incorporating a Quinoline Moiety Molecules, 21(7)
Sutton S K, Carter D R, Kim P, Tan O, Arndt G M, X D Zhang, Baell J, Noll B D, Wang S, Kumar N, et al (2016) A Novel Compound Which Sensitizes Braf Wild-Type Melanoma Cells to Vemurafenib in a Trim16-Dependent Manner Oncotarget, 7(32), 52166-78
Kim P Y, Tan O, Liu B, Trahair T, Liu T, Haber M, Norris M D, Marshall G M and Cheung B B (2016) High Tdp43 Expression Is Required for Trim16-Induced Inhibition of Cancer Cell Growth and Correlated with Good Prognosis of Neuroblastoma and Breast Cancer Patients Cancer Letters, 374(2), 315-23
Cheung B B, Tan O, Koach J, Liu B, Shum M S Y, Carter D R, Sutton S, Pouha S T, Chesler L, Haber M, et al (2015) Thymosin-Β4 Is a Determinant of Drug Sensitivity for Fenretinide and Vorinostat Combination Therapy in Neuroblastoma Molecular Oncology, 9(7), 1484-500
Kim P Y, Tan O, Diakiw SM, Carter D, Sekerye EO, Wasinger VC, Liu T, Kavallaris M, Norris M D, Haber M, et al (2014) Identification of Plasma Complement C3 as a Potential Biomarker for Neuroblastoma Using a Quantitative Proteomic Approach Journal of Proteomics, 96, 1-12
Sutton S K, Koach J, Tan O, Liu B, Carter D R, Wilmott J S, Yosufi B, Haydu L E, Mann G J, Thompson J F, et al (2014) Trim16 Inhibits Proliferation and Migration through Regulation of Interferon Beta 1 in Melanoma Cells Oncotarget, 5(20), 10127-39
P Y Kim, A S Rahmanto, O Tan, M D Norris, M Haber, G M Marshall and B B Cheung (2013) Trim16 Overexpression Induces Apoptosis through Activation of Caspase-2 in Cancer Cells Apoptosis, 18(5), 639-51
Z J Zhao, G Z Shen, L Y Tan, D W Kang, M J Want, W Kang, W X Guo, M J B Zeppel, Q Yu, J Q Li (2013) Treeline dynamics in response to climate change in the Min Mountains in southwestern China. Botanical Studies 54: 15
B B Cheung, J Koach, O Tan, P Kim, J L Bell, C DAndreti, S Sutton, A Malyukova, E Sekyere, M Norris, et al (2012) The Retinoid Signalling Molecule, Trim16, Is Repressed During Squamous Cell Carcinoma Skin Carcinogenesis in Vivo and Reduces Skin Cancer Cell Migration in Vitro. Journal of Pathology, 226(3), 451-6
Grants and Funding
- Deborah Schofield, Owen Tan, Rupendra Shrestha, Melanie Zeppel (2018) The costs of childhood cancer, Children’s Cancer Institute $200,000.
- Louisa Gordon, Nicholas Grave, Penelope Webb, Deborah Schofield, Rupendra Shrestha, Khurshid Alam, Owen Tan, Luke Rynehart, Sharyn Lymer, Sarah West (2017) Evaluation of clinical genomics projects in action. Queensland Genomics Health Alliance (QGHA) Round 1 Project Fund. $480,000 over 2 years.