Melanie Zeppel

Melanie Zeppel



Dr Melanie Zeppel
Senior Research Fellow, Health Economics
GenIMPACT: Centre for Economic Impacts of Genomic Medicine

Contact Details
P: +61 2 9850 4764
A: Room 435, Level 3, 4 Eastern Rd, Macquarie University NSW 2109   Map

Dr Melanie Zeppel researches genomic medicine, data analytics and microsimulation modelling at GenIMPACT, the National Centre for the Economic Impact of Genomic Medicine at Macquarie University. Her research involves data analysis and publishing on genomic testing, and microsimulation models. She researches the translation of genomic testing, whole exome sequencing, and whole genome sequencing, and the impact of genetic diagnosis on diagnostic pathways, and the resultant costs and benefits to individuals and government.

She was awarded Scopus Researcher of the Year 2019 for Australia and New Zealand in November 2019.



Deborah Schofield, Melanie Zeppel, Robert Tanton, Lennert Veerman, Simon Kelly, Megan Passey, Rupendra Shrestha (2019) Informal caring for back pain: overlooked costs of back pain and projections to 2030. Pain 24 Dec 2019
doi: 10.1097/j.pain.0000000000001788 [epub ahead of printing]

D Schofield, M J B Zeppel, R Tanton, J L Veerman, S J Kelly, M E Passey, R N Shrestha (2019) Intellectual disability and autism: socioeconomic impacts of informal caring, projected to 2030. BJ Psych 215(5) p 654-660

Melanie Zeppel, William Anderegg, Henry D. Adams, Patrick Hudson, Alicia Cook, Rhizwana Rumman, Derek Eamus, David T Tissue, Stephen W Pacala (2019) . Embolism recovery strategies and nocturnal water loss across species influenced by biogeographic origin. Ecology and Evolution 2019;1-14

Deborah Schofield, Rupendra N Shrestha, Melanie J B Zeppel, Michelle M Cunich, Robert Tanton, Jacob Lennert Veerman, Simon J Kelly, Megan E Passey (2019) Economic costs of informal care for people with chronic diseases in the community: lost income, extra welfare payments, and reduced taxes from 2015-2030. Health and Social Care in the Community 27(2): 493-501 (E-Pub ahead of Print 30 October 2018)


Schofield D J, Zeppel M J B, Tan O, Lymer S, Cunich M M & Shrestha R N (2018). A Brief, Global History of Microsimulation Models in Health: Past Applications, Lessons Learned and Future Directions. International Journal of Microsimulation, 11(1): 97-142

Shrestha R, Schofield D, Zeppel M J B, Cunich M M, Tanton R, Kelly S J, . . . Passey M E (2018). Care&WorkMOD: An Australian Microsimulation Model Projecting the Economic Impacts of Early Retirement in Informal Carers. International Journal of Microsimulation, 11(3) 78-99

Klein T, Zeppel M J B, Anderegg W R L, Bloemen J M G, De Kauwe J, et al (2018) Xylem embolism refilling and resilience against drought-induced mortality in woody plants: processes and trade-offs Ecological Research, 1-17


Adams H D, Zeppel M J B, Anderegg W R L, Hartmann H, Landhäusser S M (2017) A multi-species synthesis of physiological mechanisms in drought-induced tree mortality Nature Ecology & Evolution 1 (9), 1285

Zolfaghar S, Villalobos-Vega R, Zeppel M, Cleverly J, Rumman R, et al (2017) Transpiration of Eucalyptus woodlands across a natural gradient of depth-to-groundwater.Tree Physiology 37 (7), 961-975

Lombardozzi D L, Zeppel M J B, Fisher R A, Tawfik A (2017) Representing nighttime and minimum conductance in CLM4 5: global hydrology and carbon sensitivity analysis using observational constraints Geoscientific Model Development 10 (1), 321-331

Cobb R C, Ruthrof K X, Breshears D D, Lloret F, Aakala T, Adams H D, Zeppel M J B et al (2017) Ecosystem dynamics and management after forest die‐off: a global synthesis with conceptual state‐and‐transition models Ecosphere 8 (12)


Macinnis-Ng C M O, Zeppel M J B, Palmer A R, Eamus D (2016) Seasonal variations in tree water use and physiology correlate with soil salinity and soil water content in remnant woodlands on saline soils. Journal of Arid Environments 129, 102-110

Garcia‐Forner N, Adams H D, Sevant S, Collins A D, Dickman L T, Zeppel M J B et al (2016) Responses of two semiarid conifer tree species to reduced precipitation and warming reveal new perspectives for stomatal regulation Plant, Cell & Environment 39 (1), 38-49


Zeppel M J B, Harrison S P, Adams H D, Kelley D I, Li G, Tissue D T, Dawson T E, Fensham R, Medlyn B E, Palmer A, West A G, McDowell N G (2015) Drought and Resprouting plants New Phytologist 206 (2), 583-589

Anderegg W R L, Hicke J A, Fisher R A, et al Tague, C, Zeppel, MJB (2015) Tree mortality from drought, insects, and their interactions in a changing climate New Phytologist, 208 (3), 674-683

Hartmann H, Adams H D, Anderegg, WRL, Jansen S, Zeppel, MJB (2015) Research frontiers in drought‐induced tree mortality: crossing scales and disciplines. New Phytologist 205 (3), 965-969

Zolfaghar S, Villalobos-Vega R, Zeppel M, Eamus D (2015) The hydraulic architecture of Eucalyptus trees growing across a gradient of depth-to-groundwater Functional Plant Biology 42 (9), 888-898

Lombardozzi DL, Zeppel MJB, Fisher RA, Tawfik A (2015) Observed nighttime conductance alters modeled global hydrology and carbon budgets Geoscientific Model Development Discussions 8 (12)


S Zolfaghar, R Cleverly, J Villalobos-Vega, M J B Rumman, R Zeppel, D Eamus (2014) The influence of depth-to-groundwater on structure and productivity of Eucalyptus woodlands. A J Botany 62: 5 428-437

M J B Zeppel, J D Lewis, N Phillips, D T Tissue (2014) Consequences of nocturnal water loss: a synthesis of implications for capacitance, embolism, and use in models. Tree Physiology 34: 10 1047-1055

M J B Zeppel, J Wilks, J D Lewis (2014) Impacts of extreme precipitation and seasonal changes in precipitation on plants. Biogeosciences 11: 3083-3093

L Chen, Zhang, M J B Zeppel, C Liu, J Guo, J Zhu, T Zha (2014) Response of transpiration to rain pulses for two tree species in a semi-arid plantation International Journal of Biometeorology 58: 1569-1581


Nate G McDowell, Michael G Ryan, Melanie J B Zeppel, David T Tissue (2013) Feature: Improving our knowledge of drought-induced forest mortality through experiments, observations, and modelling. The New Phytologist 200: 2 289-293 Oct

Jeffrey A Hicke, Melanie J B Zeppel (2013) Climate-driven tree mortality: insights from the piñon pine die-off in the United States. The New Phytologist 200: 2 301-303 Oct

Z J Zhao, G Z Shen, L Y Tan, D W Kang, M J Want, W Kang, W X Guo, M J B Zeppel, Q Yu, J Q Li (2013) Treeline dynamics in response to climate change in the Min Mountains in southwestern China. Botanical Studies 54: 15

C C Zhou, Y Luo, M J B Zeppel (2013) System dynamics simulation of soil water resources with data support from the Yucheng Comprehensive Experimental Station, North China. Hydrol Res 44: 4 690-705

R Whitley, D Taylor, C Macinnis-Ng, M J B Zeppel, Yunusa, I OGrady, A, R Froend, B Medlyn, D Eamus (2013) Developing an empirical model of canopy water flux describing the common response of transpiration to solar radiation and VPD across five contrasting woodlands and forests. Hydrological Processes 27: 1133-1146

M J B Zeppel (2013) Convergence of tree water use and hydraulic architecture in water-limited regions: a review and synthesis. Ecohydrology 6: 5 889-900


L Xiaowei, F Guobin, M J B Zeppel, Y Xiubo, Z Gang, D Eamus, Y Qiang (2012) Probability Models of Fire Risk Based on Forest Fire Indices in Contrasting Climates over China. Journal of Resources and Ecology 3: 105-117

I Yunusa, S Zolfaghar, M J B Zeppel, Z Li, A Palmer, D Eamus (2012) Fine Root Biomass and Its Relationship to Evapotranspiration in Woody and Grassy Vegetation Covers for Ecological Restoration of Waste Storage and Mining Landscapes. Ecosystems 15: 1 113-127

M J B Zeppel, J D Lewis, B Chaszar, R A Smith, B E Medlyn, T E Huxman, D T Tissue (2012) Nocturnal stomatal conductance responses to rising [CO2], temperature and drought. New Phytologist 193: 929-938


M J B Zeppel, J D Lewis, Belinda E Medlyn, Craig V M Barton, Remko A Duursma, D Eamus, M A Adams, N Phillips, David S Ellsworth, M Forster, D T Tissue (2011) Interactive effects of elevated CO2 and drought on nocturnal water fluxes in Eucalyptus saligna. Tree Physiology 31: 9 932-944

I A M Yunusa, S Fuentes, A Palmer, C Macinnis-Ng, C Zeppel, D Eamus (2011) Latent heat fluxes during two contrasting years from a juvenile plantation established over a waste disposal landscape.  Journal of Hydrology 399: 48-56

R J Whitley, C Macinnis-Ng, L B Hutley, J Beringer, M J B Zeppel, M Williams, D Taylor, D Eamus (2011) Is productivity of mesic savanna light limited or water limited? Results of a simulation study. Global Change Biology 17: 3130-3149

G Sun, K Alstad, J Chen, S Chen, C R Ford, G Lin, C Liu, N Lu, S G McNulty, H Miao, A Noormets, J M Vose, B Wilske, M Zeppel, Y Zhang, Z Zhang (2011) A general predictive model for estimating monthly ecosystem evapotranspiration. Ecohydrology 4: 245-255

B E Medlyn, R A Duursma, M J B Zeppel (2011) Forest productivity under climate change: a checklist for evaluating model studies. Wiley Interdisciplinary Reviews: Climate Change

C Macinnis-Ng, M J B Zeppel, M Williams, D Eamus (2011) Applying a SPA model to examine the impact of climate change on GPP of open woodlands and the potential for woody thickening. Ecohydrology 4: 3 379-393


C Macinnis-Ng, S Fuentes, A P OGrady, A Palmer, D T Taylor, R J Whitley, I A M Yunusa, M Zeppel, M Hardie, D Eamus (2010) Root biomass distribution and soil properties of an open woodland on a duplex soil. Plant and Soil 327: 1

A R Palmer, S Fuentes, D Taylor, C M O Macinnis-Ng, M J B Zeppel, I A M Yunusa, D Eamus (2010) Towards a spatial understanding of water use of several land-cover classes: an examination of relationships amongst pre-dawn leaf water potential, vegetation water use, aridity and MODIS LAI. Ecohydrology 3: 1-10

M J B Zeppel, D Tissue, D T Taylor, C Macinnis-Ng, D Eamus (2010) Rates of nocturnal transpiration in two evergreen temperate woodland species with differing water-use strategies. Tree Physiology 30: 988-1000

I A M Yunusa, M J B Zeppel, S Fuentes, C Macinnis-Ng, A R Palmer, D Eamus (2010) An assessment of the water budget for contrasting vegetation covers associated with waste management. Hydrological Processes 24 1149-1158


A R Palmer, S Fuentes, D Taylor, C Macinnis-Ng, M Zeppel, I Yunusa, E February, D Eamus (2008) The use of pre-dawn leaf water potential and MODIS LAI to explore seasonal trends in the phenology of Australian and southern African woodlands and savannas. Australian Journal of Botany 56: 7 557-563

R Whitley, M Zeppel, N Armstrong, C Macinnis-Ng, I Yunusa, D Eamus (2008) A modified Jarvis-Stewart model for predicting stand-scale transpiration of an Australian native forest. Plant and Soil 305: 1-2 35-47

I A M Yunusa, M J B Zeppel, I K Nuberg (2008) Water-use efficiency reflects management practices in Australian olive groves. Journal of Horticultural Science & Biotechnology 83: 2 232-238

M J B Zeppel, C M O Macinnis-Ng, C R Ford, D Eamus (2008) The response of sap flow to pulses of rain in a temperate Australian woodland. Plant and Soil 305: 1-2 121-130

M J B Zeppel, C M O Macinnis-Ng, I A M Yunusa, R J Whitley, D Eamus (2008) Long term trends of stand transpiration in a remnant forest during wet and dry years. Journal of Hydrology 349: 1-2 200-213

M Zeppel, D Eamus (2008) Coordination of leaf area, sapwood area and canopy conductance leads to species convergence of tree water use in a remnant evergreen woodland. Australian Journal of Botany 56: 2 97-108

M J B Zeppel, C Macinnis-Ng, A Palmer, D Taylor, R Whitley, S Fuentes, I Yunusa, M Williams, D Eamus (2008) An analysis of the sensitivity of sap flux to soil and plant variables assessed for an Australian woodland using a soil-plant-atmosphere model. Functional Plant Biology 35: 6 509-520

Michael J Hill, Udaya Senarath, Alex Lee, M J B Zeppel, Joanne M Nightingale, Richard, Tim R McVicar (2006) Assessment of the MODIS LAI product for Australian ecosystems. Remote Sensing of Environment 101: 4 495-518

M J B Zeppel, I A M Yunusa, D Eamus (2006) Daily, seasonal and annual patterns of transpiration from a stand of remnant vegetation dominated by a coniferous Callitris species and a broad-leaved Eucalyptus species. Physiologia Plantarum 127: 3 413-422

D Eamus, C M Macinnis-Ng, G C Hose, M J B Zeppel, D T Taylor, B M Murray (2005) Turner Review No 9: Ecosystem services: an ecophysiological examination. Australian Journal of Botany 53: 1-19

M J B Zeppel, D Eamus (2005) Tree water use under conditions of drought. Agricultural Science 17: 3 8-11

M J B Zeppel, B R Murray, C Barton, D Eamus (2004) Seasonal responses of xylem sap velocity to VPD and solar radiation during drought in a stand of native trees in temperate. Australia Functional Plant Biology 31: 461-470

M J B Zeppel, B R Murray, D Eamus (2003) The potential impact of dryland salinity on the threatened flora and fauna of New South Wales. Ecological Management and Restoration 4 (Supplement): 53-59

Grants and Funding

Melanie Zeppel, Deborah Schofield, Rupendra Shrestha, Sophie Lewis, Sarah Perkins (2020) Costs of heat waves on health: vulnerable communities and regions. 20-22 MQ Research Seeding Grant M Zeppel 110378583 IntFun, $26,898, 2020-2022

Graham P, Zeppel M, Lee E, Kyng T, Beggs P (2019) Excess costs of heat waves on hospital admissions due to violent crime. MQBS Research Accelerator Project Scheme. $10,000

Deborah Schofield, Owen Tan, Rupendra Shrestha, Melanie Zeppel (2018) The costs of childhood cancer, Children’s Cancer Institute $200,000.

Macquarie University, Wright, Westoby, Prentice, et al. (2012-2013) Research Infrastructure Grant. Upgrading Plant Physiology teaching equipment $85,000

Chief Investigators including Medlyn, Zeppel. (2012) MQSIS, Macquarie University Teaching and Learning Funding. Plant Physiology teaching equipment $45,000

Zeppel, Melanie Macquarie University top up grant (2012-2015) Shifting rainfall from spring to autumn: tree growth and water use under climate change. $25,000

Zeppel, Melanie (2011) Shifting rainfall from spring to autumn: water use under climate change. Australian Research Council (ARC) Discovery Early Career Researcher. 2012-2015. $375,000

Zeppel, Melanie Macquarie University Research Fellowship. Water fluxes under climate change in Australian trees. 2010-2012. $330,000

Derek Eamus, Mark Adams, Dr Melanie Zeppel. Spatially integrated estimates of landscape water fluxes. 2008-2010. ARC Discovery 2008: $240,000

Armstrong, Zeppel et al. Uni Technology, Syd (UTS). Challenge Grant. A soil-vegetation-atmosphere model for Australian forests. 2006-2007. $50,000

Zeppel and Macinnis. UTS Early Career Researcher Grant. Measuring tree water use in Australian ecosystems. 2006-2007. $24,000

Zeppel, Melanie CRC for Greenhouse Accounting.  Impacts of salinity on plant growth and water use. 2002-2005. $20,000

Zeppel and Eamus. Australian Institute of Agricultural Science & Technology: Tree water use and growth under drought. 2003-2004. $3,000

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