The spread of neurodegeneration in the visual pathways
Mres Yr 2 + PhD
19 May 2020 12am AEST
30 Jun 2020 12am AEST
Scholarship available to
This is an excellent project for candidates who wish to develop a career in the field of ophthalmic and neuroscience research. The student will use a combination of cell biology, transgenic animal models of disease, gene therapy and human clinical studies to determine the mechanisms of neurodegeneration in the visual system. Research will apply cutting edge biochemistry, molecular biology, electrophysiology, imaging and clinical tools to develop novel methods with an application to neurodegenerative diseases.
In neurodegenerative disorders, evidence of degenerative changes usually occur in specific brain regions and then spread to new anatomically connected areas. This leads to degeneration of large-scale human brain networks, accompanied by worsening clinical deficits. This pathological feature, termed transsynaptic degeneration, is thought to contribute to the pathology of numerous disorders in the central nervous system. Our team use the visual pathway as a model to study transsynaptic neurodegeneration because it has a unique hierarchical architecture with less complex neural projections than other brain regions. The aim of this project is to determine the mechanisms of transsynaptic neurodegeneration in the visual pathways. While focused on the visual system, this study will have broad therapeutic implications for all major neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases and multiple sclerosis.
Candidates should be enthusiastic and dedicated, with a background in biomedical sciences or clinical studies. The successful applicant will benefit from being supervised by experts in the fields of neuroscience, biochemistry, proteomics, bioinformatics, ophthalmology and vision sciences.
This scholarship is available to eligible candidates to undertake an MRes Year 2 (1-year) + PhD (3-year) program.
The scholarship is comprised of the Tuition Fee Offset and a Macquarie University Research Excellence Scholarship (MQRES) Living Allowance/Stipend.
The stipend component of the scholarship is currently valued at AUD $28,092 per annum (2020 rate, tax exempt).
Name: A/Prof. Yuyi You
Phone: +61 (2) 98123933