Development and Application of New Fluorescent Probes for Yeast Surface Display

Development and Application of New Fluorescent Probes for Yeast Surface Display

Programs Available

Cotutelle PhD (available to domestic candidates or French nationals) 

Reference Number

20202779 

Opening Date

11 Feb 2020 12am AEDT 

Closing Date

09 Apr 2020 12am AEST 

Scholarship available to

Domestic 

Description

The aim of this project is to design and synthesize a new class of long Stokes’ shift fluorophores based on the structure of epicocconone and conjugate these to drugs and natural products and apply these probes to the discovery of the drug’s cellular protein target(s) using Yeast Surface Display (YSD) of human cDNA libraries.

Epicocconone is a natural product that has been commercialised based on its unique properties. The aim of this project is to design and synthesize a new class of long Stokes shift fluorophores based on the structure of epicocconone and to develop a toolbox for labelling a range of drugs and natural products based on cleaver use of orthogonal chemistry. The second critical aspect of this project is to develop YSD as a platform technology for the rapid identification of human proteins that bind to bioactive small molecules and natural products. This will leverage state-of-the-art facilities at Macquarie University and the Université Rouen, France, working in a multidisciplinary team with expertise in synthetic biology and chemical biology.

This is a Cotutelle Scholarship funded by the XL-Chem program in Normandy and Macquarie University.  The successful student will spend 1.5-2 years in Rouen and 1.5-2 years in Sydney. A Master degree or First Class Honours in Organic Chemistry/Medicinal Chemistry/Chemical Biology are required. An interest in organic synthesis, fluorescence and chemical biology is essential.

This scholarship is available to domestic candidates or French nationals.

Availability

This Cotutelle scholarship is available to eligible candidates to undertake a direct entry 3-year PhD program.

Scholarship Components

The scholarship is comprised of a Tuition Fee Offset and a Living Allowance Stipend while on campus at Macquarie University (for a period of 18 months). The value and tenure of the scholarship is an iMQRES full-time stipend rate of $28,092 per annum (2020 rate, tax exempt and indexed annually).

Contact Details

Name: Prof. Peter Karuso FRACI FRSN and Dr Xavier Franck
Email: peter.karuso@mq.edu.au OR xavier.franck@insa-rouen.fr
Phone: 61 2 98508290

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