Protein-biomolecular assemblies  Analytical techniques to characterize protein-biomolecular assembly interactions for intelligent drug design to combat health problems such as antimicrobial resistance

Protein-biomolecular assemblies  Analytical techniques to characterize protein-biomolecular assembly interactions for intelligent drug design to combat health problems such as antimicrobial resistance

Faculty

Science and Engineering

Project Name

Protein-biomolecular assemblies - Analytical techniques to characterize protein-biomolecular assembly interactions for intelligent drug design to combat health problems such as antimicrobial resistance

Project Description

Intelligent drug design, whether it is to combat antimicrobial resistance (AMR), cancer, or other diseases, requires understanding of how a drug interacts with the molecular assemblies in cells. Even after identifying putative biomolecular targets, traditional molecular assay methods are not appropriate to characterise the interaction because of the overall size, complexity, and dynamic heterogeneity of molecular drug targets. We critically need to develop new sensitive and high-throughput analytical techniques to identify modes of action. Two complementary cross-discipline collaborative PhD studentships are available in the Department of Molecular Sciences at Macquarie University to work with Professor Alison Rodger to develop and apply new techniques based on optical spectroscopy and flow microscopy to assess the mode of action of potential drugs. This work holds the potential to provide a step-change in our ability to rapidly and quantitatively screen potential antimicrobial drugs for new modes of action with further application to the full range of drug discovery challenges.

Project 1: Identifying the modes of action of antibiotic peptides. In collaboration with Margaret Brimble, University of Auckland

Project 2: Measuring and visualizing flow oriented biomacromolecular assemblies. In collaboration with Ravi Jagadeeshan, Monash University002E

For more details see link at: https://www.mq.edu.au/about/about-the-university/faculties-and-departments/faculty-of-science-and-engineering/departments-and-centres/department-of-molecular-science/our-research

Other important information:  Domestic applications are encouraged in the first instance to apply but international applications will also be considered from candidates who are deemed suitable to the project also.

Contact

Alison Rodger
Alison.rodger@mq.edu.au 
+61426627077

This scholarship is available to eligible candidates to undertake a direct entry 3 year PhD program.

The value and tenure of the scholarship is:

  • The MQRES full-time stipend rate is $27,082 per annum (in 2018 tax exempt for up to 3 years (indexed annually)
  • The scholarship is comprised of a Tuition Fee Offset and a Living Allowance Stipend.

Applicants will need to complete a HDR Candidature and Scholarship Application Form and arrange for two academic referee reports to be submitted to the Higher Degree Research Office. The application form and further information can be found on the Application page.   

To be eligible for a scholarship, applicants are expected to have a record of excellent academic performance and preferably, additional relevant research experience and/or peer-reviewed research activity, awards and/or prizes in line with the University’s scholarship rating guidelines. Refer to the Rating Scholarship Applicants section for more information about these guidelines.

Macquarie University will advise the successful applicant of entitlements at the time of scholarship offer.

Please quote the allocation number on your application.

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