Assessment of known and candidate motor neuron disease genes using in vitro and in vivo models

Assessment of known and candidate motor neuron disease genes using in vitro and in vivo models

Faculty

Medicine and Health Sciences

Project Name

Assessment of known and candidate motor neuron disease genes using in vitro and in vivo models

Project Description

The only proven causes of MND are gene mutations that lead to motor neuron death. Identification of genes that cause or predispose to MND will unravel the underlying molecular mechanisms as a prerequisite to effective disease diagnosis, treatment and prevention. Using cutting edge genetics, genomics and bioinformatics tools, our group has identified novel MND causing gene mutations from familial MND patients (published in Science, Nature Communications and Nature Neuroscience), as well as candidate gene mutations. The overall aim of this project is to identify novel MND gene mutations as well as to investigate the functional consequences of mutations. This study will involve a wide range of cell biology, biochemistry and histology techniques, including advanced confocal microscopy, stem cell culture, CRISPR genome editing, flow cytometry, immunohistochemistry, western blotting, as well as transgenic zebrafish and/or mouse models.

Contact:

A/Prof Ian Blair
Ian.blair@mq.edu.au
(02) 98502725

Dr Shu Yang
shu.yang@mq.edu.au
(02) 98502728

This scholarship is available to eligible candidates to undertake a direct entry into a 3 year PhD program.

The value and tenure of the scholarship is:

  • The MQRTP full-time stipend rate is $26,682 per annum (in 2017 tax exempt, for up to 3 years (indexed annually)
  • The scholarship is comprised of a Tuition Fee Offset and a Living Allowance Stipend.

Applicants will need to complete a HDR Candidature and Scholarship Application Form and arrange for two academic referee reports to be submitted to the Higher Degree Research Office. The application form and further information can be found on the Application page.

To be eligible for a scholarship, applicants are expected to have a record of excellent academic performance and preferably, additional relevant research experience and/or peer-reviewed research activity, awards and/or prizes in line with the University’s scholarship rating guidelines. Refer to the Rating Scholarship Applicants section for more information about these guidelines.

Macquarie University will advise the successful applicant of entitlements at the time of scholarship offer.

Please quote the allocation number on your application.

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