Current methods used for colorectal cancer screening are inadequate on both sensitivity and specificity grounds while morbidity and mortality of this malignancy remain high. Minimally invasive blood-based tests may overcome this issue.
At the moment clinically used and established biomarkers are found in low concentrations of blood. This is thought to stem from structural changes in the microenvironment of cancer tissues through the dilution of blood. Sadia Mahboob’s research looked to apply this knowledge to colorectal cancer.
Through gaining access to an extensive sample size – obtained from the Victoria Biobank – Sadia evaluated the suitability of plasma for biomarker discovery. This involved a proteomic investigation to identify the expression of potential cancer biomarkers using new state-of-the-art technological breakthroughs. Sadia’s research has gone a long way to developing a blood-based biosignature panel that will assist with early detection, diagnosis and prognosis of colorectal cancer.