Non-invasive assessment of cerebrospinal fluid pressure

Cerebrospinal fluid (CSF) is produced in the cavities of the brain and circulates around the brain tissue acting as a cushion between the brain and skull. Cerebral dysfunction is diagnosed by changes in CSF pressure (CSFp). Because of infection risk caused by invasive surgical procedures for measuring CSFp, a non-invasive method for assessment of CSFp is desirable. This project aims to measure CSFp non-invasively using the vessels of the ocular circulation. Non-invasive dynamic optical techniques are used to detect changes in retinal vessel calibre and to develop relations between these changes and CSFp located at the back of the eye.