Medical research

Medical research

Adipose-derived cells in osteoarthritis

Chief investigators: Herbert, Packer, Vesey

Grant details
Provided by: Australian Research Council


Body fluids: sweet protection against infection?

Chief investigators: Packer, Nevalainen, Wilcox, Paulsen

Summary
We propose that the human innate immune system actually uses the infection mechanism of pathogens to its own advantage. The first step of bacterial and fungal infection is adhesion of the microorganism to the mucosal surface of the host epithelia.

We will show that secreted fluids that bathe these surfaces use these same protein-sugar interactions to bind the pathogens, which can then be expelled physically from the body. Tears and saliva will be used to determine whether their glycoproteins protect the eye and oral cavity respectively from infection by the main pathogens to which they are exposed. This knowledge will provide opportunities for the development of new and natural antimicrobial agents.

Grant details
Provided by: Australian Research Council Discovery Projects


Cortical link between cardiovascular health and mental illness

Chief investigators: Cornish, Haynes, Goodchild

Summary
We are using a novel integration of behavioural, cardiovascular and molecular techniques to discover the neurotransmitter and cellular basis of prefrontal cortex function. This will form part of a larger investigation to investigate in detail the neurotransmitters of the prefrontal cortex that regulate cardiovascular function and how changes to brain function (induced by methamphetamine exposure or environmental enrichment) alter the role of the prefrontal cortex and related circuits.

Grant details
Provided by: Macquarie University research and development grant


Developing new treatments for brain arteriovenous malformations: Identification of endothelial protein targets

Chief investigators: Stoodley, Molloy, Tu, Morgan, Smee

Grant details
Provided by: National Health and Medical Research Council


Inflammatory determinants for colorectal cancer treatment

Chief investigators: Charles, Molloy, Clarke

Grant details
Provided by: National Health and Medical Research Council


Mother’s sweet milk: boosting the baby’s protection against infection

Chief Investigators: Packer, Nevalainen, Paulsen, Power

Grant details
Provided by: Macquarie University internal research grant


Multiplexed quantitation of phosphoproteins in tumours as prognostic markers

Chief investigator: Molloy

Grant details
Provided by: Cancer Institute NSW (Innovation grant)


Plasma biomarkers for clinical outcome of colorectal cancer

Chief investigator: Molloy

Grant details
Provided by: Macquarie University safety net grant


Protein biomarkers of colorectal cancer

Chief investigator: Molloy

Grant details
Provided by: National Health and Medical Research Council (Careers Development Award)


The role of the interaction between sugars and proteins in the protection against pathogenic infection

Chief Investigator: Packer

Grant details
Provided by: Macquarie University Internal Research Grant

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