Associate Professor Ann K Goodchild
Systems and Signalling Neuroscience Group
The Australian School of Advanced Medicine, Macquarie University
The Australian School of Advanced Medicine
2 Technology Place, Macquarie University NSW 2109, Australia
Tel: +61 (0)2 9850 2711
Fax: +61 (0)2 9850 2701
Areas of Research Interest
The goal of the Systems and Signalling Neuroscience Group is to understand how neurons and neuronal networks operate normally, such as in health and what changes underpin their dysfunction evident in disease. The neural systems of interest are those which control cardiovascular, metabolic and respiratory function.
The specific objectives of our group are: to identify neurons in the central nervous system that regulate or modify these functions; to understand the circuitry by which they influence the key brain sites that control the functions of interest, to determine the neurochemistry of the neurons and receptor and downstream intracellular signalling mechanisms that influence their activity; to determine neuronal recruitment/adaptation and protein changes/modifications that occur within these neural systems in response to acute or chronic challenges. Acute challenges include altering blood sugar levels, blood pressure or drugs of addiction. Chronic challenges include hypertension, diabetes, and mental health disorders including depression, schizophrenia and methamphetamine addiction. These challenges alter the function of neurons and we are examining the cellular and molecular mechanisms responsible.
Active collaborations include those with Professor Roger Dampney (University of Sydney), Professor Paul Gray (University of Washington, USA), A/Prof Jennifer Cornish (Psychology, Macquarie University), Professor Nicki Packer (CBMS, Macquarie University), Professor Peter Dunkley (University of Newcastle) and Dr Simon McMullan (ASAM).
Techniques used include in vivo and in vitro electrophysiological techniques in conjuction with pharmacology, functional neuroanatomy using multilabelling approaches as well as 'shot gun' label and label free proteomic techniques. We welcome enquiries for study at the Masters or PhD level. Please feel free to discuss your options by email or phone at any time.
- Associate Professor, The Australian School of Advanced Medicine, Macquarie University
- Honorary Associate Professor, School of Medical Sciences, University of Sydney
Funding (from 2010)
- 2012-14 AK Goodchild, S McMullan, P Gray Which neurons maintain vasomotor tone? Project Grant $548,675
- 2012-14 S McMullan, AK Goodchild, AM Allen Mapping the connectome that controls blood pressure Discovery Project $320,000
- 2012-14 JK Phillips, AK Goodchild, CM Hildreth Reduced Baroreceptor Reflex Control Of Heart Rate In Chronic Renal Failure Project Grant $473,675
- 2012 Hillcrest Foundation (Perpetual) AK Goodchild JL Cornish Role of serotonin in prefrontal cortex $50,000
- 2010-11 National Heart Foundation Grant-in aid, Goodchild and Kumar, "Brain calcium signalling controlling arterial blood pressure" $129,000
- 2011 Hillcrest Foundation (Perpetual), AK Goodchild Role of Prefrontal cortex in autonomic function $50,000
- 2010 Hunter Medical Research Institute, L Bobrovskaya, AK Goodchild and PR Dunkley Project grant The central neural pathway that controls the release of catecholamines from the adrenal medulla: is it impaired in hypertension? $24, 686
- 2010 Hillcrest Foundation (Perpetual), Goodchild " Depression and cardiovascular function" $50,000
- 2010 Macquarie Safety Net, Goodchild, "Parallel central pathways controlling adrenal medullary function" $18,400
- 2010 Macquarie Development Grant Cornish, Goodchild and Haynes, "Cortical link between cardiovascular health and mental illness" $49,000
- 2010 others and AK Goodchild ARC-Phosphorylation and glycosylation Linkage Infrastructure, Equipment and Facilities (LIEF) LE100100150 $500,000
- 2010 others and AK Goodchild Super-resolution fluorescence microscopy ARC-Linkage Infrastructure, Equipment and Facilities (LIEF) LE100100089 $700,000
- 2007-2010 NHMRC Project grant, Goodchild, "G alpha proteins and their effectors (AC, PLC, rho and ERK) in central cardiovascular regulation in health and disease" $611,250
- Damanhuri HA, Burke PGR, Ong LK, Bobrovskaya L,Dickson P Dunkley PR and Goodchild AK (2013) Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: a marker of activation following acute hypotension and glucoprivation. PLoS ONE accepted 26th October
- Pardey, M, Kumar NN, Goodchild AK, Cornish JL (2012) Catecholamine receptors differentially mediate impulsive choice in the medial prefrontal and orbitofrontal cortex Journal of Psychopharmacology (in press)
- Pardey, M, Kumar NN, Goodchild AK, Clemens K, Homewood J, Cornish JL (2012) Long-term effects of chronic oral Ritalin administration on cognitive and neural development in non-ADHD adolescent rats Brain Science (in press)
- Bowman BR, Kumar NN, Hassan SF, McMullan S, Goodchild AK (2012) Brain sources of inhibitory input to the rat rostral ventrolateral medulla. Journal of Comparative Neurology in press
- Sreenivasan VK, Kim EJ, Goodchild AK, Connor M, Zvyagin AV (2012) Targeting somatostatin receptors using in situ-bioconjugated fluorescent nanoparticles Nanomedicine 7(10) 1551-1560
- Parker LP, Tallapragada VJ, Kumar NN and Goodchild AK (2012) Distribution and localisation of Gα proteins in the rostral ventrolateral medulla of normotensive and hypertensive rats: focus on catecholaminergic neurons Neuroscience 218:20-34.
- Sreenivasan VK, Stremovskiy OA, Kelf TA, Heblinski M, Goodchild AK, Connor M, Deyev SM, Zvyagin AV. (2011) Pharmacological characterization of a recombinant,fluorescent somatostatin receptor agonist. Bioconjug Chem. 22(9):1768-75.
- Burke PG, Neale J, Korim WS, McMullan S, Goodchild AK (2011) Patterning of somatosympathetic reflexes reveals nonuniform organization of presympathetic drive from C1 and non-C1 RVLM neurons. Am J Physiol Regul Integr Comp Physiol. 301(4):R1112-22.
- Hildreth CM, Goodchild AK. (2010) Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the rat. BMC Neurosci. 11:128.
- 0. Bobrovskaya L, Damanhuri HA, Ong LK, Schneider JJ, Dickson PW, Dunkley PR, Goodchild AK. (2010) Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: an in vivo analysis. Neurochem Int. 57(2):162-7. IF=2.9
- 1. Burke PG, Abbott SB, McMullan S, Goodchild AK, Pilowsky PM. (2010) Somatostatin selectively ablates post-inspiratory activity after injection into the Bötzinger complex. Neuroscience;167(2):528-39.
- 2. Allen K, Parker L, Damanhuri H, Goodchild AK. (2010) Neuropeptide coding of sympathetic preganglionic neurons; focus on adrenally projecting populations. Neuroscience 170:789-799.
- Dr Mehdi Mirzaei (post doctoral fellow)
- Phill Bokiniec (Research Assistant)
- Sophie Fletcher (Research Assistant)
- Belinda Bowman
- Hanafi Damanhuri
- Sarah Hassan
- Lindsay Parker
- Suead Zumut
- Catherine Radford (2013)
- International Society for Autonomic Neuroscience Executive Committee: Treasurer
- High Blood Pressure Research Council of Australia Executive Committee member: Editor
- MQ Partnerships and Infrastructure Panel Committee Member
- Chairperson of the Building Renovation committee
- Faculty Research Subcommittee member
- ASAM Research Advisory Committee deputy chair