Neurobiology, Faculty of Medicine and Health Sciences
A/Prof Atkin a neuroscientist and cell biologist with an international reputation in the field of ALS/MND. Her work involves identification of the major cellular signalling pathways that trigger motor neuron death in ALS/MND, and how these pathways can be modulated. This work aims to develop novel therapeutic strategies for ALS/MND, based on inhibiting the fundamental mechanisms that trigger neurodegeneration in this disorder.
PhD (Sheffield, UK), Grad Dip (RMIT), BSc(Hons) (Manchester, UK).
- Molecular and cellular mechanisms leading to neurodegeneration in ALS/MND and FTD.
- Modulation of Endoplasmic Recticulum homeostasis as a novel therapeutic strategy in ALS/MND
- Structural and functional properties of proteins relevant to ALS/MND
- M A Farg, V Sundaramoorthy, J M Sultana, S Yang, R A. K. Atkinson, V
Levina, M A Halloran, P Gleeson, I P Blair, K Y Soo, A E King, J D Atkin
“C9ORF72, implicated in ALS and FTD, regulates endosomal trafficking” Hum Mol Genet., Jul 1; 23(13):3579-95 (2014)
- Soo KY, Halloran M,
Sundaramoorthy V, Parakh S, K A. Southam, Lock P, King A, Farg MA, Atkin JD
“Rab1-dependent ER-Golgi Transport Dysfunction is a Common Pathogenic Mechanism in SOD1, TDP-43 and FUS-associated ALS”
- Soo KY, Sultana J, , King A, Atkinson R, Warraich ST, Sundaramoorthy V,
Blair I, Farg MA, Atkin JD
“ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1” Cell Death Discovery (2015), 1, 105030
- Williams KL, Topp S, Yang S,
Smith B, Fifita JA, ….Yerbury JJ, Atkin JD, Shaw CE, Nicholson GA, Blair
IP. “CCNF mutations in amyotrophic lateral sclerosis and frontotemporal
Nature Commun. (2016) 15;7:11253.
- Parakh S, Atkin JD. “Protein folding alterations in ALS.”
Brain Res. (2016) doi:10.1016/j.brainres.2016.04.010
- 2015-2019 NHMRC Project Grant $664,154
“Disruption to intracellular trafficking as a central pathogenic mechanism in ALS”
J D Atkin CIA, N Cole CIB, R Chung CIC
- 2015-2020 NHMRC Dementia Research Team
Grants $6.5 million
“Developing insight into the molecular origins of familial and sporadic frontotemporal dementia and ALS”
I Blair CIA, J D Atkin CIB, R Chung CIC, G Guillemin, CID, L Ooi CIE, W Wilson, CIF, M Molloy GIG, J Yerbury CIH, N Cole CII, T Karl CIJ
- 2016 MND
Research Institute of Australia, Cure for MND Foundation Grant, $99,950
“DNA damage and neurodegeneration in ALS”
J D Atkin, S Cutts